Contact Information

• 영문이름 : KYUNG TAE LEE
• 전공분야 : 생화학 
• 학      위 : 1991년 Katholike University Leuven 의과대학 대학원 졸업 (의학박사)
• 연 락 처 :  02-961-0860 
• 연 구 실 : 약학대학관 211호  
• 직      책 : 교수
• 담당과목 : 약품생화학, 내분비학, 약품생물학
• E-mail : ktlee@khu.ac.kr
• 홈페이지 : 

• 연구정보 : https://khu.elsevierpure.com/en/persons/kyung-tae-lee

• 1983년 2월 경희대학교 약학과 졸업 (약학사)

• 1985년 2월 경희대학교 대학원 졸업 (약학석사)

• 1991년 Katholike University Leuven 의과대학 대학원 졸업 (의학박사)

• 논문: The plasma native alkaline phosphatase is a phosphotyresyl phosphatase

• 1984-1985 경희의료원 약사

• 1985-1986 대한민국 육군 소위 (예비역 사관 6기)

• 1993-1995 경희대학교 강사

• 1995-현재 경희대학교 조교수, 부교수, 교수

• 1995-현재 보건복지부 중양약사심의위원

• 1995-현재 대한약학회 평의원

• 1995-현재 한국약제학회 편집위원

• 1995-현재 한국생약학회 이사

• 1999-현재 한국응용약물학회 평의원

• 2008-현재 한국식품영양과학회 편집위원

[수상경력]

• 2007 한국약제학회 학술상 우수논문

• 2008 경희의료원 고황의학상 우수논문

• 2009 경희 Fellow 우수논문

• 항암 및 항염증 효능 검색, 기전 연구 및 약물 개발

• 면역증강 효능 검색, 기전 연구 및 약물 개발

• 항피부노화 효능 검색, 기전 연구 및 약물 개발

• 마크로파지 polarization 조절 기전 연구

• 염증성 질환과 microbiota 상관성 연구

• 생물학적 동등성 시험(식약처 인증기관 약물 분석 및 CYP등 DDI 조절기전)

• 약리 활성 검색, 기전 연구 및 표적 발굴과 약물 개발(피부노화 및 보습, 비만)

• mPGES-1을 표적으로 하는 관절염 치료제 개발

• 2018년

Immunostimulatory effects of cordycepin‐enriched WIB‐801CE from Cordyceps militaris in splenocytes and cyclophosphamide‐induced immunosuppressed mice

Phytotherapy Research 2018;32:132–139

9-Hydroxycanthin-6-one isolated from stem bark of Ailanthus altissima induces ovarian cancer cell apoptosis and inhibits the activation of tumor-associated macrophages.

Chemico-Biological Interactions 280 (2018) 99–108

Iloprost, a prostacyclin analog, inhibits the invasion of ovarian cancer cells by downregulating matrix metallopeptidase-2 (MMP-2) through the IP-dependent pathway

Prostaglandins and Other Lipid Mediators 134 (2018) 47–56

Asymmetric dimethylarginine (ADMA) is identified as a potential biomarker of insulin resistance in skeletal muscle

Scientific Reports (2018) 8:2133

Kaempferol 7-O-β-D-glucoside isolated from the leaves of Cudrania tricuspidata inhibits LPS-induced expression of pro-inflammatory mediators through inactivation of NF-κB, AP-1, and JAK-STAT in RAW 264.7 macrophages

Chemico-Biological Interactions 284 (2018) 101–111

Dammarane-type triterpene ginsenoside-Rg18 inhibits human non-small cell lung cancer A549 cell proliferation via G1 phase arrest.

Oncology Letters 15: 6043-6049, 2018

Phytotherapeutic Activities of Sanguisorba officinalis and its Chemical Constituents: A Review

The American Journal of Chinese Medicine, Vol. 46, No. 2, 1–20

Deoxyschizandrin, Isolated from Schisandra Berries, Induces Cell Cycle Arrest in Ovarian Cancer Cells and Inhibits the Protumoural Activation of Tumour-Associated Macrophages.

Nutrients 2018, 10, 91;

Synthetic 3′,4′-Dihydroxyflavone Exerts Anti-Neuroinflammatory Effects in BV2 Microglia and a Mouse Model Biomolecules & Therapeutics 26(2), 210-217 (2018)

Compound K induced apoptosis via endoplasmic reticulum Ca2+ release through ryanodine receptor in human lung cancer cells

Journal of Ginseng Research 2018;42:165e174

Sanguisorba officinalis extract, ziyuglycoside I, and II exhibit antiviral effects against hepatitis B virus European Journal of Integrative Medicine 20 (2018) 165–172

A Novel Phenylsulfonamide Ameliorates the Cognitive Impairment in Mice Induced by Scopolamine

Bulletin of the Korean Chemical Society 2018, Vol. 39, 891–894

Iridoids from the Roots of Patrinia scabra and Their Inhibitory Potential on LPS-Induced Nitric Oxide Producti on

Journal of Natural Products 2018 Jun 22;81(6):1468-1473.

Preclinical Evaluation of In Vitro and In Vivo Antiviral Activities of KCT-01, a New Herbal Formula against Hep atitis B Virus

Evidence-Based Complementary and Alternative Medicine 2018 Jul 4;2018:1073509.

Cirsimarin, a flavone glucoside from the aerial part of Cirsium japonicum var. ussuriense (Regel) Kitam. ex Ohwi, suppresses the JAK/STAT and IRF-3 signaling pathway in LPS-stimulated RAW 264.7 macrophages

Chemico-Biological Interactions 2018 Sep 25;293(2018):38-47.

Design, synthesis and biological evaluation of novel thiazolidinedione derivatives as irreversible allosteric IKK -β modulators

European Journal of Medicinal Chemistry 2018 Sep 5;157(2018):691-704.

Synthesis of new triarylpyrazole derivatives possessing terminal sulfonamide moiety and their inhibitory effects on PGE2 and nitric oxide productions in lipopolysaccharide-induced RAW 264.7 macrophages

Molecules 2018 Oct 7;23(10):E2556.

Panaxydol Derived from Panax ginseng Inhibits G1 Cell Cycle Progression in Non-small Cell Lung Cancer via Upregulation of Intracellular Ca2+ Levels

Biological & Pharmaceutical Bulletin 2018;41(11):1701-1707.

Novel Rhodanine Derivative, 5-[4-(4-Fluorophenoxy) phenyl]methylene-3-{4-[3-(4-methylpiperazin-1-yl)propoxy]phenyl}-2-thioxo-4-thiazolidinone dihydrochloride, Induces Apoptosis via Mitochondria Dysfunction and Endoplasmic Reticulum Stress in Human Colon Cancer Cells

Molecules 2018 Nov 6;23(11):E2895.

Pharmacokinetic and bioequivalence study comparing a fimasartan/rosuvastatin fixed-dose combination with the concomitant administration of fimasartan and rosuvastatin in healthy subjects

Drug Design, Development and Therapy 2018 Oct 26;12:3607–3615.

23-Hydroxyursolic Acid Isolated from the Stem Bark of Cussonia bancoensis Induces Apoptosis through Fas/Caspase-8-Dependent Pathway in HL-60 Human Promyelocytic Leukemia Cells

Molecules 2018 Dec 13;23(12):E3306.

• 2017년

Anti-colitis effect of Lactobacillus sakei K040706 via suppression of inflammatory responses in the dextran sulfate sodium-induced colitis mice model

Journal of Functional Foods 29 (2017) 256–268

Pharmacokinetic Interactions Between Pelubiprofen and Eperisone Hydrochloride:ARandomized, Open-label, Crossover Study of Healthy Korean Men

Clinical Therapeutics/Volume 39, Number 1, 2017/138-149

Ethanol Extract of Potentilla supina Linne Suppresses LPS-induced Inflammatory Responses through NF-κBand AP-1 Inactivation in Macrophages and in Endotoxic mice.

Phytother Res. 2017 Mar;31(3):475-487.

Identification and structure activity relationship of novel flavone derivatives that inhibit the production of nitricoxide and PGE2 in LPS-induced RAW 264.7 cells.

Bioorg Med Chem Lett. 2017 Jun 1;27(11):2613-2616.

Xanthotoxin suppresses LPS-induced expression of iNOS, COX-2, TNF-α, and IL-6 via AP-1, NF-κB, and JAK-STAT inactivation in RAW 264.7 macrophages.

Int Immunopharmacol. 2017 Aug;49:21-29.

Pharmacological Profiles of a Highly Potent and Long-Acting Angiotensin II Receptor Antagonist, Fimasartan, in Rats and Dogs after Oral Administration.

Biol Pharm Bull. 2017;40(7):992-1001.

Synthesis and inhibitory effects of triarylpyrazoles on LPS-induced NO and PGE2 productions in RAW 264.7 macrophages

Medicinal Chemistry Research. 26(9). 2161-2171

Development of Liquid Chromatography Tandem Mass Spectrometry Method for Determination of Mazindol in Human Plasma: Application to a Bioequivalence Study of Daewon Sanorex Tablet® (Mazindol 1 mg)

Current Pharmaceutical Analysis, 2017,13,559-565

Synthesis and biological evaluation of fluoro-substituted 3,4-dihydroquinazoline derivatives for cytotoxic and analgesic effects.

Bioorg Med Chem. 2017 Sep 1;25(17):4656-4664.

p-Coumaroyl Anthocyanin Mixture Isolated from Tuber Epidermis of Solanum tuberosum Attenuates Reactive Oxygen Species and Pro-inflammatory Mediators by Suppressing NF-κB and STAT1/3 Signaling in LPS-Indu

ced RAW264.7 Macrophages.

Biol Pharm Bull. 2017;40(11):1894-1902. doi: 10.1248/bpb.b17-00362.

Inhibitory effect of moschamine isolated from Carthamus tinctorius on LPS-induced inflammatory mediators via AP-1 and STAT1/3 inactivation in RAW 264.7 macrophages.

Bioorg Med Chem Lett. 2017 Dec 1;27(23):5245-5251.

Kyungheechunggan-Tang-01, a New Herbal Medication, Suppresses LPS-Induced Inflammatory Responses through JAK/STAT Signaling Pathway in RAW 264.7 Macrophages

Evidence-Based Complementary and Alternative Medicine Volume 2017

Gastroprotective effects of isopropanol extract of Artemisia princeps and its gastroretentive floating tablets on gastric mucosal injury

Acta Pharm. 67 (2017) 479–494

• 2016년

Amomum tsao-ko fruit extract suppresses lipopolysaccharide-induced inducible nitric oxide synthase by inducing heme oxygenase-1 in macrophages and in septic mice.

Int J Exp Pathol. 2015 Dec;96(6):395-405.

Hit-to-lead optimization of phenylsulfonyl hydrazides for a potent suppressor of PGE2 production: Synthesis,biological activity, and molecular docking study.

Bioorg Med Chem Lett. 2016 Jan 1;26(1):94-9

In vitro synergistic anticancer activity of the combination of T-type calcium channel blocker and chemotherapeutic agent in A549 cells.

Bioorg Med Chem Lett. 2016 Feb 1;26(3):1073-9.

Constituents of PG201 (Layla(®)), a multi-component phytopharmaceutical, with inhibitory activity on LPS-in duced nitric oxide and prostaglandin E2 productions in macrophages.

Arch Pharm Res. 2016 Feb;39(2):231-9.

Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.

J Nat Prod. 2016 Apr 22;79(4):711-20.

Chikusetsusaponin IVa Methyl Ester Isolated from the Roots of Achyranthes japonica Suppresses LPS-Induced iNOS, TNF-α, IL-6, and IL-1β Expression by NF-κB and AP-1 Inactivation.

Biol Pharm Bull. 2016;39(5):657-64.

Exopolysaccharide fraction from Pediococcus pentosaceus KFT18 induces immunostimulatory activity in macrophages and immunosuppressed mice.

J Appl Microbiol. 2016 May;120(5):1390-402.

Development of a Simple and Accurate RP-HPLC-UV for Determination of Choleretic Drug Alibendol in Human Plasma and Its Application for a Pharmacokinetic Study

Current Pharmaceutical Analysis, 12(3): 244-248.

Berberine Decreased Inducible Nitric Oxide Synthase mRNA Stability through Negative Regulation of Human Antigen R in Lipopolysaccharide-Induced Macrophages.

J Pharmacol Exp Ther. 2016 Jul;358(1):3-13

Enhanced Absorption Study of Ginsenoside Compound K (20-O-β-(D-Glucopyranosyl)-20(S)-protopanaxadiol) after Oral Administration of Fermented Red Ginseng Extract (HYFRG™) in Healthy Korean Volunteers an

d Rats.

Evid Based Complement Alternat Med. 2016;2016:3908142. Epub 2016 Jul 19.

α-Solanine Isolated From Solanum Tuberosum L. cv Jayoung Abrogates LPS-Induced Inflammatory Respon ses Via NF-κB Inactivation in RAW 264.7 Macrophages and Endotoxin-Induced Shock Model in Mice.

J Cell Biochem. 2016 Oct;117(10):2327-39. doi: 10.1002/jcb.25530. Epub 2016 Mar 11. Cnidilide, an alkylphthalide isolated from the roots of Cnidium officinale, suppresses LPS-induced NO, PGE

2, IL-1β, IL-6 and TNF-α production by AP-1 and NF-κB inactivation in RAW 264.7 macrophages.

Int Immunopharmacol. 2016 Aug 31;40:146-155

Isocyperol, isolated from the rhizomes of Cyperus rotundus, inhibits LPS-induced inflammatory responses via suppression of the NF-κB and STAT3 pathways and ROS stress in LPS-stimulated RAW 264.7 cells.

Int Immunopharmacol. 2016 Sep;38:61-9. doi: 10.1016/j.intimp.2016.05.017. Epub 2016 May 27.

Synthesis, structure determination, and biological evaluation of phenylsulfonyl hydrazide derivatives as potential anti-inflammatory agents.

Bioorg Med Chem Lett. 2016 Nov 1;26(21):5193-5197.

Synthesis of New Tricyclic and Tetracyclic Fused Coumarin Sulfonate Derivatives and Their Inhibitory Effectson LPS-Induced Nitric Oxide and PGE2 Productions in RAW 264.7 Macrophages: Part 2.

Arch Pharm (Weinheim). 2016 Nov;349(11):853-863.

Resveratrol analogue (E)-8-acetoxy-2-[2-(3,4-diacetoxyphenyl)ethenyl]-quinazoline induces apoptosis viaFas-mediated pathway in HL-60 human leukemia cells.

Oncol Rep. 2016 Oct 13.

Comparative Physicochemical and Pharmacokinetic Properties of Quetiapine and Its Active Metabolite Norquetiapine

Chem Pharm Bull (Tokyo). 2016;64(11):1546-1554.

6-(3,4-Dihydro-1H-isoquinoline-2-yl)-N-(6-methoxypyridine-2-yl) nicotinamide-26 (DIMN-26) decreasescell proliferation by induction of apoptosis and downregulation of androgen receptor signaling in human prostate cancer cells.

Chem Biol Interact. 2016 Dec 25;260:196-207.

•1.등록번호(출원번호): 10-1126023-0000

등록일자(출원일자): 2012.03.05

발명의 명칭: 단일 염기 다형성의 분석에 의한 탈니플루메이트의 맞춤형 투여량의 결정방법 및 그에 사용되는 유전자

출원인: 경희대학교 산학협력단

발명자: 임성빈, 곽규범, 이경태, 서지형, 김려화

•2.등록번호(출원번호): 10-1139171-0000

등록일자(출원일자): 2012.04.16(20090918)

발명의 명칭: 단일 염기 다형성의 분석에 의한 피오글리타존의 맞춤형 투여량의 결정방법 및 그에 사용되는 유전자

출원인: 경희대학교 산학협력단

발명자: 임성빈, 곽규범, 이경태, 서지형, 윤지영

•3.출원번호: 10-2011-0023364

출원일자: 2011.03.16

발명의 명칭: 3,4-디히드로퀴나졸린 이염산염 및 그를 포함하는 항암제 조성물

출원인: 동우신테크 주식회사, 경희대학교 산학협력단

발명자: 이재열 주동준 이경태 김영덕 오천림

• 4.출원번호: 10-2011-0023369

출원일자: 2011.03.16

발명의 명칭: 3,4-디히드로퀴나졸린 유도체의 제조방법 및 이를 위한 중간체

출원인: 동우신테크 주식회사, 경희대학교 산학협력단

발명자: 이재열 주동준 이경태 김영덕 오천림