서브 컨텐츠
류종훈
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• 영문이름 : Jong Hoon Ryu • 연구정보 : https://khu.elsevierpure.com/en/persons/jong-hoon-ryu |
| Education |
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서울대학교 약학대학 제약학과 약학사 |
| Career |
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경희대학교 약학대학 한약학과 교수 Visiting Scholar, University of California San Diego 2012 ~ 2015 한국보건의료인국가시험원 시험위원장 2014 ~ 2016 경희대학교 약학대학 학장 2019 President, The Korean Society of Applied Pharmacology 2022 ~ President, The Korean Society of Oriental Pharmacy |
| Research Field |
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Learning and Memory - Schizophrenia - Post Traumatic Stress Disorder - Autism Spectrum Disorder |
| Selected Publications |
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[SCI(E)급 국제 학술지, 2026년 ~] 1. Kong CH, Park K, Han JE, Bae HJ, Park SJ, Jung SY, Kim DH, Ryu JH. Sinapic acid balances the excitatory and inhibitory neurotransmitter systems to mitigate post-traumatic stress disorder-like behaviors. Life Sci.2026 Mar 1;388:124201. doi: 10.1016/j.lfs.2026.124201. Epub 2026 Jan 11. PMID: 41529730. 2. Moon S, Kwon H, Cho E, Lee S, Park SJ, Moon M, Ryu JH, Jang DS, Bae HJ, Kim DH. Swertisin improves Alzheimer's disease-like pathology in 5XFAD male mice through regulation in plasmin activity. Neurochem Int.2026 Feb;193:106118. doi: 10.1016/j.neuint.2026.106118. Epub 2026 Jan 9. PMID: 41520885. 3. Seo K, Jeon M, Han JE, Hong J, Kim DH, Choi JH, Jung SY, Kim KM, Kim DH, Ryu JH, Lee JY. α2C Adrenoceptor antagonist KMCA-0011 alleviated depressive-like behaviors in a maternal separation mouse model. Bioorg Med Chem Lett.2026 Feb 1;131:130467. doi: 10.1016/j.bmcl.2025.130467. Epub 2025 Nov 7. PMID: 41205766. [SCI(E)급 국제 학술지, 2020 ~ 2025년] 5. Kim MS, Son SR, Han JE, Kong CH, Park K, Jung SY, Jang DS, Ryu JH. Schizandrin ameliorates post-traumatic stress disorder-like behaviors via 5-HT1A receptor in mice. J Psychiatr Res.2025 Nov;191:578-589. doi: 10.1016/j.jpsychires.2025.10.003. Epub 2025 Oct 4. PMID: 41075496. 6. Zhang JB, Lu GD, Sun DN, Ding P, Chen YK, Zhou YY, Chen YT, Cai M, Ryu JH, Wang P, Liang YP. Pellitorine protects chronic restraint stress-induced cognitive deficits via inhibiting neural inflammation and ferroptosis. Int Immunopharmacol.2025 Sep 23;162:115166. doi: 10.1016/j.intimp.2025.115166. Epub 2025 Jul 2. PMID: 40609205. 7. Kwon H, Jeon J, Cho E, Moon S, Park AY, Kwon HJ, Kwon KJ, Ryu JH, Shin CY, Yi JH, Kim DH. Chronic stress-related behavioral and synaptic changes require caspase-3 activation in the ventral hippocampus of male mice. Neuropharmacology.2025 Jul 1;272:110431. doi: 10.1016/j.neuropharm.2025.110431. Epub 2025 Mar 25. PMID: 40147637. 8. Park K, Lee WH, Cho E, Kong CH, Min HS, Kim MS, Han JE, Jung SY, Kim DH, Ryu JH. The effects of Cheonwangbosim-dan, a traditional herbal medicine prescription, on scopolamine-induced cognitive dysfunction in mice. J Ethnopharmacol.2025 Mar 13;343:119500. doi: 10.1016/j.jep.2025.119500. Epub 2025 Feb 13. PMID: 39954830. 9. Jeon M, Kim MS, Kong CH, Min HS, Kang WC, Park K, Jung SY, Bae HJ, Park SJ, Lee JY, Kim JW, Ryu JH. 4-Methoxycinnamic acid ameliorates post-traumatic stress disorder-like behavior in mice by antagonizing the CRF type 1 receptor. Life Sci.2025 Jan 15;361:123271. doi: 10.1016/j.lfs.2024.123271. Epub 2024 Nov 26. PMID: 39603448. 10. Kong CH, Min HS, Jeon M, Kang WC, Park K, Kim MS, Jung SY, Bae HJ, Park SJ, Shin HK, Seo CS, Ryu JH. Cheonwangbosimdan mitigates post-traumatic stress disorder-like behaviors through GluN2B-containing NMDA receptor antagonism in mice. J Ethnopharmacol.2024 Aug 10;330:118270. doi: 10.1016/j.jep.2024.118270. Epub 2024 Apr 27. PMID: 38685368. 11. Kang WC, Lee YS, Park K, Kong CH, Jeon M, Kim MS, Jung SY, Choi JH, Ryu JH. Paeonol alleviates postmenopause-induced neuropsychiatric symptoms through the modulation of GPR30 in ovariectomized mice. J Ethnopharmacol.2024 Jun 12;327:118063. doi: 10.1016/j.jep.2024.118063. Epub 2024 Mar 15. PMID: 38493906. 12. Kong CH, Lee JW, Jeon M, Kang WC, Kim MS, Park K, Bae HJ, Park SJ, Jung SY, Kim SN, Kleinfelter B, Kim JW, Ryu JH. D-Pinitol mitigates post-traumatic stress disorder-like behaviors induced by single prolonged stress in mice through mineralocorticoid receptor antagonism. Prog Neuropsychopharmacol Biol Psychiatry.2024 Jun 8;132:110990. doi: 10.1016/j.pnpbp.2024.110990. Epub 2024 Mar 11. PMID: 38467326. 13. Park K, Kim R, Cho K, Kong CH, Jeon M, Kang WC, Jung SY, Jang DS, Ryu JH. Panaxcerol D from Panax ginsengameliorates the memory impairment induced by cholinergic blockade or Aβ₂₅₋₃₅ peptide in mice. J Ginseng Res.2024 Jan;48(1):59-67. doi: 10.1016/j.jgr.2023.08.002. Epub 2023 Aug 18. PMID: 38223823; PMCID: PMC10785420. 14. Park K, Kong CH, Kang WC, Jeon M, Lee WH, Lee J, Kim SC, Jung SY, Ryu JH. LPC20K modified from krill oil ameliorates the scopolamine-induced cognitive impairment. Behav Brain Res.2024 Mar 12;461:114836. doi: 10.1016/j.bbr.2023.114836. Epub 2023 Dec 23. PMID: 38145873. 15. Seong SH, Kim SH, Ryu JH, Jeong JW, Jung HA, Choi JS. Effects of Icariin and Its Metabolites on GPCR Regulation and MK-801-Induced Schizophrenia-Like Behaviors in Mice. Molecules.2023 Oct 27;28(21):7300. doi: 10.3390/molecules28217300. PMID: 37959720; PMCID: PMC10647531. 16. Paudel P, Choi JS, Prajapati R, Seong SH, Park SE, Kang WC, Ryu JH, Jung HA. In Vitro Human Monoamine Oxidase Inhibition and Human Dopamine D₄ Receptor Antagonist Effect of Natural Flavonoids for Neuroprotection. Int J Mol Sci.2023 Nov 1;24(21):15859. doi: 10.3390/ijms242115859. PMID: 37958841; PMCID: PMC10650131. 17. Kong CH, Cho K, Min JW, Kim JY, Park K, Kim DY, Jeon M, Kang WC, Jung SY, Lee JY, Ryu JH. Oleanolic acid alleviates the extrapyramidal symptoms and cognitive impairment induced by haloperidol through the striatal PKA signaling pathway in mice. Biomed Pharmacother.2023 Dec;168:115639. doi: 10.1016/j.biopha.2023.115639. Epub 2023 Oct 7. PMID: 37812895. 18. Kang WC, Park K, Kong CH, Kim DY, Lee YS, Jeon M, Kim MS, Jung SY, Hong J, Choi JH, Ryu JH. D-Pinitol attenuates postmenopausal symptoms in ovariectomized mice. Life Sci.2023 Nov 15;333:122147. doi: 10.1016/j.lfs.2023.122147. Epub 2023 Oct 5. PMID: 37802198. 19. Kim JY, Kong CH, Kim DY, Min JW, Park K, Jeon M, Kang WC, Jung SY, Ryu JH. Effect of D-pinitol on MK-801-induced schizophrenia-like behaviors in mice. Phytother Res.2023 Dec;37(12):5904-5915. doi: 10.1002/ptr.8002. Epub 2023 Aug 31. PMID: 37654104. 20. Kong CH, Park K, Kim DY, Kim JY, Kang WC, Jeon M, Min JW, Lee WH, Jung SY, Ryu JH. Effects of oleanolic acid and ursolic acid on depression-like behaviors induced by maternal separation in mice. Eur J Pharmacol.2023 Oct 5;956:175954. doi: 10.1016/j.ejphar.2023.175954. Epub 2023 Aug 2. PMID: 37541369. 21. Kim DY, Son SR, Kim JY, Min JW, Kong CH, Park K, Jeon M, Kang WC, Jung SY, Choi JH, Jang DS, Ryu JH. Effects of Artemisia annuaL. on postmenopausal syndrome in ovariectomized mice. J Ethnopharmacol.2023 Dec 5;317:116800. doi: 10.1016/j.jep.2023.116800. Epub 2023 Jun 16. PMID: 37331451. 22. Hassan AHE, Kim HJ, Park K, Choi Y, Moon S, Lee CH, Kim YJ, Cho SB, Gee MS, Lee D, Park JH, Lee JK, Ryu JH, Park KD, Lee YS. Synthesis and Biological Evaluation of O⁶-Aminoalkyl-Hispidol Analogs as Multifunctional Monoamine Oxidase-B Inhibitors towards Management of Neurodegenerative Diseases. Antioxidants (Basel).2023 Apr 29;12(5):1033. doi: 10.3390/antiox12051033. PMID: 37237899; PMCID: PMC10215199. 23. Bae HJ, Kim JY, Choi SH, Kim SY, Kim HJ, Cho YE, Choi YY, An JY, Cho SY, Ryu JH, Park SJ. Paeonol, the active component of Cynanchum paniculatum, ameliorated schizophrenia-like behaviors by regulating the PI3K-Akt-GSK3β-NF-κB signalling pathway in MK-801-treated mice. J Ethnopharmacol.2023 Oct 5;314:116627. doi: 10.1016/j.jep.2023.116627. Epub 2023 May 9. PMID: 37164258. 24. Bae HJ, Bae HJ, Kim JY, Park K, Yang X, Jung SY, Park SJ, Kim DH, Shin CY, Ryu JH. The effect of lansoprazole on MK-801-induced schizophrenia-like behaviors in mice. Prog Neuropsychopharmacol Biol Psychiatry.2023 Jan 10;120:110646. doi: 10.1016/j.pnpbp.2022.110646. Epub 2022 Sep 30. PMID: 36191804. 25. Jeon SJ, Kwon H, Bae HJ, Gonzales EL, Kim J, Chung HJ, Kim DH, Ryu JH, Shin CY. Agmatine relieves behavioral impairments in Fragile X mice model. Neuropharmacology.2022 Nov 15;219:109234. doi: 10.1016/j.neuropharm.2022.109234. Epub 2022 Aug 31. PMID: 36057317. 26. Kendir G, Bae HJ, Kim J, Jeong Y, Bae HJ, Park K, Yang X, Cho YJ, Kim JY, Jung SY, Köroğlu A, Jang DS, Ryu JH. The effects of the ethanol extract of Cordia myxaleaves on the cognitive function in mice. BMC Complement Med Ther.2022 Aug 10;22(1):215. doi: 10.1186/s12906-022-03693-z. PMID: 35948926; PMCID: PMC9367120. 27. Yi JH, Moon S, Cho E, Kwon H, Lee S, Jeon J, Park AY, Lee YH, Kwon KJ, Ryu JH, Shin CY, Yi JH, Kim DH. Hyperoside improves learning and memory deficits by amyloid β₁₋₄₂ in mice through regulating synaptic calcium-permeable AMPA receptors. Eur J Pharmacol.2022 Sep 15;931:175188. doi: 10.1016/j.ejphar.2022.175188. Epub 2022 Aug 7. PMID: 35948162. 28. Cho KS, Joo SH, Choi CS, Kim KC, Ko HM, Park JH, Kim P, Lee SH, Bahn GH, Ryu JH, Lee J, Han SH, Kwon KJ, Shin CY. Corrigendum to "Glucose deprivation reversibly down-regulates tissue plasminogen activator via proteasomal degradation in rat primary astrocytes" [Life Sci. 92 (2013) 929-937]. Life Sci.2022 Oct 1;306:120796. doi: 10.1016/j.lfs.2022.120796. Epub 2022 Jul 15. Erratum for: Life Sci.2013 May 20;92(17-19):929-37. doi: 10.1016/j.lfs.2013.03.011. PMID: 35851480. 29. Bae HJ, Kim J, Bae HJ, Park K, Yang X, Cho YJ, Jung SY, Park SJ, Ryu JH. Effects of repetitive training on learning and memory performance of TLR2 KO mice. Behav Brain Res.2022 May 24;426:113836. doi: 10.1016/j.bbr.2022.113836. Epub 2022 Mar 9. PMID: 35278481. 30. Jeon J, Mony TJ, Cho E, Kwon H, Cho WS, Choi JW, Kim BC, Ryu JH, Jeon SJ, Kwon KJ, Shin CY, Park SJ, Kim DH. Role of extracellular signal-regulated kinase in rubrofusarin-enhanced cognitive functions and neurite outgrowth. Biomed Pharmacother.2022 Mar;147:112663. doi: 10.1016/j.biopha.2022.112663. Epub 2022 Jan 29. PMID: 35093759. 31. Jeong Y, Bae HJ, Park K, Bae HJ, Yang X, Cho YJ, Jung SY, Jang DS, Ryu JH. 4-Methoxycinnamic acid attenuates schizophrenia-like behaviors induced by MK-801 in mice. J Ethnopharmacol.2022 Mar 1;285:114864. doi: 10.1016/j.jep.2021.114864. Epub 2021 Nov 23. PMID: 34822958. 32. Botanas CJ, Perez Custodio RJ, Kim HJ, de la Pena JB, Sayson LV, Ortiz DM, Kim M, Lee HJ, Acharya S, Kim KM, Lee CJ, Ryu JH, Lee YS, Cheong JH. Corrigendum to 'R (-) methoxetamine exerts rapid and sustained antidepressant effects and fewer behavioral side effects relative to S (+)-methoxetamine' [Neuropharmacology 193 (2021) 108619]. Neuropharmacology.2021 Nov 1;199:108804. doi: 10.1016/j.neuropharm.2021.108804. Epub 2021 Sep 22. Erratum for: Neuropharmacology.2021 Aug 1;193:108619. doi: 10.1016/j.neuropharm.2021.108619. PMID: 34563364. 33. Paudel P, Seong SH, Park SE, Ryu JH, Jung HA, Choi JS. In Vitro and In Silico Characterization of G-Protein Coupled Receptor (GPCR) Targets of Phlorofucofuroeckol-A and Dieckol. Mar Drugs.2021 Jun 4;19(6):326. doi: 10.3390/md19060326. PMID: 34199834; PMCID: PMC8228075. 34. Botanas CJ, Perez Custodio RJ, Kim HJ, de la Pena JB, Sayson LV, Ortiz DM, Kim M, Lee HJ, Acharya S, Kim KM, Lee CJ, Ryu JH, Lee YS, Cheong JH. R (-)-methoxetamine exerts rapid and sustained antidepressant effects and fewer behavioral side effects relative to S (+)-methoxetamine. Neuropharmacology.2021 Aug 1;193:108619. doi: 10.1016/j.neuropharm.2021.108619. Epub 2021 May 20. Erratum in: Neuropharmacology.2021 Nov 1;199:108804. doi: 10.1016/j.neuropharm.2021.108804. PMID: 34023336. 35. Yi JH, Kwon H, Cho E, Jeon J, Lee J, Lee YC, Cho JH, Jun M, Moon M, Ryu JH, Kim JS, Choi JW, Park SJ, Lee S, Kim DH. REDD1 Is Involved in Amyloid β-Induced Synaptic Dysfunction and Memory Impairment. Int J Mol Sci.2020 Dec 13;21(24):9482. doi: 10.3390/ijms21249482. PMID: 33322202; PMCID: PMC7763153. 36. Yu J, Cho E, Kwon H, Jeon J, Seong Sin J, Kwon Park J, Kim JS, Woong Choi J, Jin Park S, Jun M, Choon Lee Y, Hoon Ryu J, Lee J, Moon M, Lee S, Hyun Cho J, Hyun Kim D. Akt and calcium-permeable AMPA receptor are involved in the effect of pinoresinol on amyloid β-induced synaptic plasticity and memory deficits. Biochem Pharmacol.2021 Feb;184:114366. doi: 10.1016/j.bcp.2020.114366. Epub 2020 Dec 11. PMID: 33310049. 37. Goo N, Bae HJ, Park K, Kim J, Jeong Y, Cai M, Cho K, Jung SY, Kim DH, Ryu JH. The effect of fecal microbiota transplantation on autistic-like behaviors in Fmr1 KO mice. Life Sci.2020 Dec 1;262:118497. doi: 10.1016/j.lfs.2020.118497. Epub 2020 Sep 25. PMID: 32987062. 38. Kim DH, Kwon H, Choi JW, Shin CY, Cheong JH, Park SJ, Ryu JH. Roles of GABAA receptor α5 subunit on locomotion and working memory in transient forebrain ischemia in mice. Prog Neuropsychopharmacol Biol Psychiatry.2020 Aug 30;102:109962. doi: 10.1016/j.pnpbp.2020.109962. Epub 2020 May 16. PMID: 32428535. 39. Yi JH, Jeon J, Kwon H, Cho E, Yun J, Lee YC, Ryu JH, Park SJ, Cho JH, Kim DH. Rubrofusarin Attenuates Chronic Restraint Stress-Induced Depressive Symptoms. Int J Mol Sci.2020 May 13;21(10):3454. doi: 10.3390/ijms21103454. PMID: 32414166; PMCID: PMC7278964. 40. Kim J, Seo YH, Kim J, Goo N, Jeong Y, Bae HJ, Jung SY, Lee J, Ryu JH. Casticin ameliorates scopolamine-induced cognitive dysfunction in mice. J Ethnopharmacol.2020 Sep 15;259:112843. doi: 10.1016/j.jep.2020.112843. Epub 2020 May 4. PMID: 32380246. 41. Bae HJ, Kim J, Jeon SJ, Kim J, Goo N, Jeong Y, Cho K, Cai M, Jung SY, Kwon KJ, Ryu JH. Green tea extract containing enhanced levels of epimerized catechins attenuates scopolamine-induced memory impairment in mice. J Ethnopharmacol.2020 Aug 10;258:112923. doi: 10.1016/j.jep.2020.112923. Epub 2020 May 1. PMID: 32360798. 42. Bae HJ, Kim J, Kim J, Goo N, Cai M, Cho K, Jung SY, Kwon H, Kim DH, Jang DS, Ryu JH. The effect of maslinic acid on cognitive dysfunction induced by cholinergic blockade in mice. Br J Pharmacol.2020 Jul;177(14):3197-3209. doi: 10.1111/bph.15042. Epub 2020 Apr 1. PMID: 32133639; PMCID: PMC7312314. 43. Ha S, Lee H, Choi Y, Kang H, Jeon SJ, Ryu JH, Kim HJ, Cheong JH, Lim S, Kim BN, Lee DS. Maturational delay and asymmetric information flow of brain connectivity in SHR model of ADHD revealed by topological analysis of metabolic networks. Sci Rep.2020 Feb 21;10(1):3197. doi: 10.1038/s41598-020-59921-4. PMID: 32081992; PMCID: PMC7035354. 44. Deepa P, Bae HJ, Park HB, Kim SY, Choi JW, Kim DH, Liu XQ, Ryu JH, Park SJ. Dracocephalum moldavicaattenuates scopolamine-induced cognitive impairment through activation of hippocampal ERK-CREB signaling in mice. J Ethnopharmacol.2020 May 10;253:112651. doi: 10.1016/j.jep.2020.112651. Epub 2020 Feb 6. PMID: 32035879. 45. Oh J, Kim DH, Kim GY, Park EJ, Ryu JH, Jung JW, Park SJ, Kim GW, Lee S. Hydrangeae Dulcis FoliumAttenuates Physical Stress by Suppressing ACTH-Induced Cortisol in Zebrafish. Chin J Integr Med.2020 Feb;26(2):130-137. doi: 10.1007/s11655-019-3204-6. Epub 2019 Dec 23. PMID: 31872368. 46. Cai M, Jung I, Kwon H, Cho E, Jeon J, Yun J, Lee YC, Kim DH, Ryu JH. Spinosin Attenuates Alzheimer's Disease-Associated Synaptic Dysfunction via Regulation of Plasmin Activity. Biomol Ther (Seoul).2020 Mar 1;28(2):131-136. doi: 10.4062/biomolther.2019.076. PMID: 31791115; PMCID: PMC7059816. 47. Han HS, Shin JS, Song YR, Rhee YK, Cho CW, Ryu JH, Inn KS, Hong HD, Lee KT. Immunostimulatory effects of polysaccharides isolated from young barley leaves (Hordeum vulgareL.) with dual activation of Th1 and Th2 in splenic T cells and cyclophosphamide-induced immunosuppressed mice. Int J Biol Macromol.2020 Mar 15;147:954-964. doi: 10.1016/j.ijbiomac.2019.10.062. Epub 2019 Nov 12. PMID: 31730956. 48. Koo B, Bae HJ, Goo N, Kim J, Kim J, Cai M, Jung IH, Cho K, Jung SY, Chang SW, Jang DS, Ryu JH. A botanical drug composed of three herbal materials attenuates the sensorimotor gating deficit and cognitive impairment induced by MK-801 in mice. J Pharm Pharmacol.2020 Jan;72(1):149-160. doi: 10.1111/jphp.13199. Epub 2019 Nov 12. PMID: 31713882. 49. Lee CB, Min JS, Chae SU, Kim HM, Jang JH, Jung IH, Zheng YF, Ryu JH, Bae SK. Simultaneous determination of donepezil, 6-O-desmethyl donepezil and spinosin in beagle dog plasma using liquid chromatography-tandem mass spectrometry and its application to a drug-drug interaction study. J Pharm Biomed Anal.2020 Jan 30;178:112919. doi: 10.1016/j.jpba.2019.112919. Epub 2019 Oct 13. PMID: 31654856. |
| Book & patent |
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[특허] [저서] |
